Topical clotrimazole is categorized as pregnancy category B. It can be taken by mouth as a lozenge or troche or applied as a topical cream to the skin or in the vagina. Īdditionally, clotrimazole may be used to treat the sickling of cells (related to sickle cell anemia). Topical and oral clotrimazole can be used in both adults and children. Topical clotrimazole cream, when combined with mechanical reduction of the nail, has been demonstrated to be effective in the treatment of onychomycosis - fungal infection of the fingernails and toenails. The preferred treatment of tinea infections is therefore with clotrimazole monotherapy. It can be effective in treating chronic paronychia. Combination creams are best avoided in order to improve treatment outcome, reduce the possibility of skin atrophy associated with prolonged topical glucocorticoid use, and to limit the cost of treatment. Although temporary relief and partial suppression of symptoms may be observed with the combination therapy, glucocorticoids can elicit an immunosuppressive response and rebound effect that results in more severe infection typically requiring systemic antifungal agents to treat the disease. Although FDA approved, clotrimazole–betamethasone combination cream is not the preferred treatment for dermatophyte infections due to increased side effects from the topical glucocorticoid. Ĭlotrimazole may be compounded with a glucocorticoid, such as betamethasone, in a topical cream for the treatment of tinea corporis (ringworm), tinea cruris (jock itch) and tinea pedis ( athlete's foot). Ĭlotrimazole is usually used five times daily for 14 days for oral thrush, twice daily for 2 to 8 weeks for skin infections, and once daily for 3 or 7 days for vaginal infections. Throat lozenge preparations are used for oropharyngeal candidiasis ( oral thrush) or prevention of oral thrush in people with neutropenia. When using over-the-counter drug clotrimazole products, use should be discontinued if condition does not improve after treatment for 2 weeks for jock itch or after 4 weeks for athlete's foot or ringworm. Topical clotrimazole is usually not effective in treatment of fungal infections of the scalp or nails. For vulvovaginal candidiasis, clotrimazole tablets and creams are inserted into the vagina. Topically, clotrimazole is used for vulvovaginal candidiasis (yeast infection) or yeast infections of the skin. It is also available as an oral troche or throat lozenge as a prescription only. It is commonly available without a prescription in various dosage forms, such as a topical cream, ointment, or vaginal suppository. It is on the World Health Organization's List of Essential Medicines. It is in the azole class of medications and works by disrupting the fungal cell membrane. When used by mouth, greater care should be taken in those with liver problems. There is no evidence of harm when used by mouth during pregnancy but this has been less well studied. In pregnancy, use on the skin or in the vagina is believed to be safe. When applied to the skin, common side effects include redness and a burning sensation. Ĭommon side effects when taken by mouth include nausea and itchiness. It can be taken by mouth or applied as a cream to the skin or in the vagina. It is used to treat vaginal yeast infections, oral thrush, diaper rash, tinea versicolor, and types of ringworm including athlete's foot and jock itch. Clotrimazole, sold under the brand name Lotrimin, among others, is an antifungal medication.
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